Why Is So Different in Analysis Results Provided by the Gene Sequencing Companies?
Kira Peikoff, 28 year old expressed concern about her future health because of family disease. She hoped to find some tips and suggestions from gene sequencing. But she found that three different gene sequencing companies gave different analysis results. Since the analysis results of different companies are different, what is the significance of such sequencing?
In the human body and almost all the living body (except for some RNA viruses and prion), each cell has a complete set of genomic DNA, such as a complete blueprint + construction manual. From the beginning of the fertilized egg, the body will choose different chapters from this manual to set up different functions of the cells, and let them perform the corresponding functions. Each one of these manuals is slightly different (most of them are the aforementioned SNP). These differences define race, skin, hair, eye color and other traits, but also defines the sensitivity of the disease. Three companies have represented the genetic health consulting industry, trying to find some SNPs associated disease, to detect their state, then calculate a probability, and finally hand over in the detected hand.
What kind of SNP locus is really associated with disease? How much relationship does it have ?
The former problem basically relies on large-scale association analysis. In fact, it is a statistical concept.
Actually only a few single gene diseases (such as a type of congenital deafness) have resolute and decisive conclusions. Height, weight, hypertension, diabetes and cancer are caused by hundreds of intertwined genes, coupled with the impact of the environment factor accumulation, coupled with the time, and show the differences. So now in the human genetics, in fact, everyone is trying to increase the statistics of the population, find race and background conditions consistent with the crowd, improve the effectiveness of their study of statistics and probability as far as possible. Even so, the conclusions between different groups of researchers are different. Because they are less likely to be shared by a group of people who are selected, the conclusion is seldom that to be repeatedly verified by other groups.